Neurotransmitters are the chemical messengers that regulate mood, memory, the sleep cycle and daily stress. Adequate neurotransmitter production depends on an adequate supply of amino acids, vitamins and minerals in the diet. High levels of stress, dietary deficiencies, genetics, medications and toxins all play a role in neurotransmitter depletion. Tranqill provides the nutrients required to help optimize neurotransmitter production.
Tranqill is formulated to support a positive mental outlook and a relaxed, focused state. It includes amino acid precursors and bioactive nutrients that support healthy levels of neurotransmitters such as gamma-aminobutyric acid (GABA), serotonin, dopamine, norepinephrine and epinephrine. Maintaining adequate neurotransmitter production is vital for regulating mood, appetite, memory, focus, energy levels and a healthy sleep cycle.
4 capsules one to two times per day on an empty stomach or as recommended by your health care professional
Serving Size: 4 Capsules
|Vitamin C (as Ascorbic Acid USP)||50 mg||83%|
|Niacin (as Niacinamide USP)||10 mg||50%|
|Vitamin B6 (as Pyridoxal 5'-Phosphate)||10 mg||500%|
|Folate (as Quatrefolic® (6S)-5- Methyltetrahydrofolic acid glucosamine salt)||400 mcg||100%|
|Vitamin B12 (as Methylcobalamin)||200 mcg||3,333%|
|Magnesium (as DiMagnesium Malate)||75 mg||19%|
|Zinc (as TRAACS® Zinc Bisglycinate Chelate)||5 mg||33%|
|Inositol NF||1 g||*|
|L-Tyrosine USP||400 mg||*|
|Mucuna Pruriens Extract (Standardized to contain 10% L-Dopa)||400 mg||*|
|5-HTP (5-Hydroxytryptophan) (from Griffonia simplicifolia (Seed))||150 mg||*|
|Gamma Aminobutyric Acid (PharmaGABATM)||100 mg||*|
|* Daily Value not established|
Other Ingredients: Natural Vegetable Capsules, Magnesium Stearate, and Silicon Dioxide.
L-theanine is an amino acid found abundantly in green tea. L-theanine has been shown to quickly improve stress perception and resilience. The stress-buffering mechanisms of L-theanine have been connected to its ability to increase serotonin and dopamine production in the brain. L-theanine has also been shown to significantly increase alpha brain wave activity, which is critical for increasing attention as well as promoting a sense of relaxation.
Gamma-amino butyric acid (GABA) is one of the major inhibitory neurotransmitters in the brain. GABA provides a calming effect and is a primary component of the body’s stress fighting mechanisms. GABA is also available as dietary supplement. Most commercially available forms of GABA utilize synthetically-produced GABA, manufactured from pyrrolidinone, a compound not allowed for use in Japan. Tranqill includes a patented, naturally-sourced, non-synthetic form of GABA called PharmaGABA®. It is produced naturally by the friendly bacteria, Lactobacillus hilgardii. In contrast to synthetic GABA sources, PharmaGABA® has been shown in published research studies to promote relaxation effects in the central nervous system (CNS).
Inositol is a B vitamin that is an important component of cell membrane signaling. As part of the cellular signaling system of the CNS, inositol is crucial for the release of neurotransmitters from within the nerve cells. A deficiency of inositol can affect brain signaling, resulting in inadequate neurotransmitter release causing irritability, worry and restlessness.
5-hydroxytryptophan (5-HTP) is an amino acid intermediate that is directly converted into the mood-regulating neurotransmitter, serotonin. Maintaining a healthy serotonin level is important regulating appetite and sleep cycle and for supporting a sense of calmness. As a dietary supplement, 5-HTP is produced naturally from the seeds of the African plant, Griffonia simplifolia. In contrast to L-tryptophan, 5-HTP provides efficient conversion into serotonin because it does not need prior conversion by tryptophan hydroxylase.
L-tyrosine is an amino acid precursor to the neurotransmitters dopamine, norepinephrine and epinephrine. These neurotransmitters help regulate mood, memory and concentration. L-tyrosine is able to cross the blood-brain barrier by the large neutral amino acid (LNAA) carrier system that is present in brain capillaries. Supplementation with L-tyrosine helps to increase the concentration of available tyrosine and reduce competition among similar amino acids. Once taken up by nerve cells, tyrosine is converted to L-dopa, then to dopamine. Dopamine is either used as a neurotransmitter or as a precursor to produce norepinephrine and epinephrine.
Mucuna pruriens, commonly known as Velvet bean, includes standardized doses of L-dopa. L-dopa is the direct precursor to the neurotransmitter dopamine, which helps maintain a positive mental outlook, and motivation. It is also important for supporting cognitive function. Supplementation with M. pruriens has been shown to support neurotransmitter production. In a study of 75 men, M. pruriens supplementation significantly improved dopamine, norepinephrine and epinephrine levels compared to the control group.
Tranqill includes several nutrients that are required in synthesis pathways for the neurotransmitters serotonin, GABA, dopamine, norepinephrine and epinephrine. This includes 5-methyltetrahydrofolate (5-MTHF), vitamin B6, vitamin C, zinc and magnesium. 5-MTHF is the biologically active form of the B vitamin folic acid, which is vital to supporting proper mood regulation. 5-MTHF works together with B12 as methyl group donor. Methyl (CH3) group donation is important for maintaining neurotransmitter synthesis. Magnesium is a mineral that calms the nervous system by binding to glutamate receptors, which reduces excitatory neurotransmitter activity.