Emerging research highlights the importance of optimal intake of vitamin K and its critical role in maintaining bone and cardiovascular health. Composed of a group of naturally occurring and structurally similar, fat-soluble vitamins, vitamin K is required for the proper utilization of calcium and helps to bind newly absorbed calcium to the bone matrix. Vitamin K helps maintain bone mineral density by decreasing the activity of osteoclasts, cells which break down bone. It also provides critical cardiovascular protection by activating matrix Gla protein (MGP), a potent inhibitor of circulatory calcification. Along with vitamin D, another key nutrient required for overall wellness, these two nutrients act in synergy to support and maintain bone and cardiovascular health. Current research has found high concentration supplementation, at 180 μg/day, results in improved clinical results compared to lower-dose supplementation.
D3 with K2+ provides 180 mcg of soy-free vitamin K2 delivered in the MK-7 form, along with 5,000 IU of vitamin D3 for optimal support of bone and cardiovascular health.
1 capsule per day or as recommended by your health care professional
Serving Size: 1 Capsule
|Vitamin D3 (as Cholecalciferol)||5,000 IU||1,250%|
|Vitamin K2 (as Menaquinone-7 (MK7))||180 mcg||225%|
Other Ingredients: Natural Vegetable Capsules, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide, Stearic Acid, and Turmeric Root Extract.
> Ingredient Benefits
Calcium and vitamin D are important mediators in bone growth, but vitamin K plays an equally important role. The synthesis of bone growth is dependent on vitamin K, through its carboxylation of osteocalcin, a protein secreted by osteoblasts. Osteocalcin guides calcium into bones and prevents its absorption into organs, joint spaces and arteries. Vitamin K occurs in three main forms: K1 (phylloquinone), found primarily in the liver, naturally occurs in green leafy vegetables and is considered to be the main dietary source; K2 (menaquinone), which is a group name for a family of related compounds differentiated by their side chains; and K3 (menadione), which does not have vitamin K activity.
MK-4 and MK-7 are the two subclasses of K2 most widely studied for their role in bone and cardiovascular health. MK-4 is primarily a metabolic byproduct of K1 while MK-7 is found in small quantities in liver mitochondria and other tissues.The MK-7 form is substantially more active, has a longer half-life and accumulates to higher concentrations in serum than vitamin K1. The different degrees of bioavailability between K1 and K2 are due to differences in structure. The long side-chain of vitamin K2 (specifically MK-7) allows it to bind with fat particles in circulation. This process then allows easier facilitation to soft tissue, bones and arteries. More recently, research has shown that doses of 180 mcg of MK-7 provide greater results when supporting both bone and cardiovascular health.