Optimal sinus health requires proper circulation through the sinus cavities that is free of mucus build-up. The sinuses are composed of hollow cavities that are lined with soft tissue, called mucosa. Under healthy conditions, the sinuses are empty and contain a thin layer of mucus. A healthy process that occurs in the sinus cavities, termed mucociliary clearance, allows the ciliated epithelium (hair-like structures located on tissues), in coordination with mucus production, to continually remove waste from the sinuses by facilitating drainage and particle removal. Typical particles that collect in the sinus cavities include dust, pollen, dirt, allergens and fungi. SineAssist contains a synergistic blend of ingredients that support sinus health by increasing mucociliary clearance, decreasing the build-up of mucus and boosting immune response during seasonal respiratory challenges.
SineAssist is a specialized preparation of botanicals and nutrients formulated to support immune health and provide immediate support for respiratory challenges. The standardized botanicals and nutrients in SineAssist target sinus related issues by clearing airway passages, decreasing the viscosity of mucus and supporting immune health.
3 capsules per day or as recommended by your health care professional
Serving Size: 3 Capsules
|N-Acetyl-L Cysteine USP||750 mg||*|
|Andrographis paniculata Leaf Extract (Standardized to contain 30% Andrographolides)||300 mg||*|
|Thyme Extract (Whole Leaves and Flowers)||300 mg||*|
|Turmeric Root Extract (Standardized to contain 95% Curcuminoids)||300 mg||*|
|Eleuthero Root Extract (Standardized to contain 0.8% Eleutherosides)||250 mg||*|
|Bromelain (2,400 GDU/g) (from Pineapple)||200 mg||*|
|Berberine Hydrochloride Hydrate||100 mg||*|
|Licorice Root Extract (Standardized to contain 12% Glycyrrhizin Complex)||100 mg||*|
|* Daily Value not established|
Other Ingredients: Natural Vegetable Capsules, Magnesium Stea- rate, and Silicon Dioxide.
N-acetyl cysteine (NAC) is a powerful amino acid that dissolves mucus by breaking up disulfide bonds which make up the protein network that contributes to mucus density. This results in improved drainage out of the sinus cavity. In a double-blind study examining 12 healthy volunteers with slow mucociliary clearance, NAC administration for 60 days resulted in a 35% increase in mucociliary clearance rate in treated subjects, compared to no improvement in the placebo group. Additional studies have also demonstrated an improvement in mucus clearance following NAC administration.
Turmeric Root Extract
Curcumin is a yellow-colored plant pigment found in the spice, turmeric. SineAssist contains turmeric which is standardized to contain 95% curcumin. Research shows that curcumin affects numerous molecules that support healthy inflammatory response.
Bromelain is a plant enzyme that is naturally found in the stem and fruit of the pineapple plant. Bromelain exerts a synergistic effect when combined with NAC due to its proteolytic (protein-digesting) effects. Bromelain has been shown to be effective at thinning nasal secretions and provides an additional benefit of balancing inflammatory response.
Berberine Sulfate Hydrate
Berberine sulfate is a botanical extract found in the roots and barks of various plants including Oregon grape root, barberry and goldenseal. Berberine extract has been shown to support immune response by increasing blood flow to the spleen and by activating immune compounds such as macrophages. Berberine maintains healthy sinus function by quieting localized inflammatory response- Berberine has been shown to inhibit activator protein 1 (AP-1) and inhibits thromboxane A2 from platelets.
Licorice Root Extract
Licorice root has been used in Western and Eastern cultures for thousands of years. Licorice’s health-promoting benefits include soothing respiratory irritation. The active components in licorice, glycyrrhizin and glycyrrhetinic acid, strengthen immune response by inducing interferon activity, activating macrophages and augmenting natural killer cell activity. Glycyrrhizin exerts its inflammatory balancing response by inhibiting the production of reacted oxygen species released by neutrophils.
Andrographis paniculata is a plant that has been used in Asian medicine for centuries. The immune boosting properties of andrographis have been research extensively in clinical studies- Per the analysis of seven double-blind controlled trials, andrographis has been shown to be a safe botanical for supporting upper respiratory tract health.
Recent studies utilizing the combination of Eleuthero and Andrographis have demonstrated the combination of herbs to be particularly helpful for patients with upper respiratory challenges.
Thyme has been traditionally used to help soothe sinuses and loosen phlegm. Thymol, the active ingredient in thyme, also has immune supporting properties and competes with pathogens commonly found throughout the sinuses and respiratory tract. The German Commission E has approved thyme to help support respiratory challenges.