One Skin

OneSkin’s products are centered on a proprietary peptide called OS-01, designed to target cellular senescence, a fundamental biological process linked to skin aging. As skin cells age or are damaged by stressors like UV exposure, some enter a senescent state—no longer functioning properly but releasing inflammatory signals that accelerate aging in nearby cells. OS-01 is designed to reduce these harmful signals, helping calm chronic inflammation and support healthier cellular behavior. This approach aims to improve skin aging at its biological root, not just at the surface.

Laboratory testing on human skin models shows that OS-01 can shift gene expression associated with aging toward a more youthful profile, including improvements in markers tied to collagen production, epidermal thickness, and skin barrier integrity. OneSkin also reports clinical testing over 12 weeks demonstrating measurable improvements in hydration, elasticity, barrier function, and the appearance of fine lines and wrinkles.

What makes OneSkin distinct is its focus on skin health and function, not just cosmetic smoothing. By targeting aging pathways at the cellular level, the products aim to help skin behave more like younger skin—stronger, more resilient, and better able to repair itself—while still delivering visible improvements in texture and appearance over time.